Intel's 1986 ICCD paper Performance Optimizations of the 80386 reveals how tightly this was optimized. The entire address translation pipeline -- effective address calculation, segment relocation, and TLB lookup -- completes in 1.5 clock cycles:
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A common mechanism of inhibition of the essential lipid II flippase MurJ by three distinct phage-encoded single-gene lysis proteins provides insights into potential new targets for antimicrobial development.